個(gè)人簡介

武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院教授，博士生導(dǎo)師；2012年入選武漢市“黃鶴英才計(jì)劃”；2013年入選“教育部新世紀(jì)優(yōu)秀人才計(jì)劃”；2015年獲聘武漢大學(xué)珞珈特聘教授；2022年獲聘武漢大學(xué)-中南醫(yī)院交叉研究院特聘教授。已發(fā)表學(xué)術(shù)論文110余篇，獲授權(quán)發(fā)明專利3項(xiàng)；獲2005年湖北省自然科學(xué)一等獎(jiǎng)1項(xiàng)（排名第2）、教育部2012年度“高等學(xué)校十大科技進(jìn)展”1項(xiàng)（排名第3）。”現(xiàn)擔(dān)任Bioactive Carbohydrates and Dietary Fibre期刊編委 (2015-現(xiàn)在)。近5年主持國家自然科學(xué)基金3項(xiàng)、國家重點(diǎn)研發(fā)計(jì)劃子課題1項(xiàng)。

教育經(jīng)歷

1997年6月,畢業(yè)于武漢大學(xué)化學(xué)系獲理學(xué)學(xué)士學(xué)位

2000年5月,赴日本大阪大學(xué)從事高分子溶液理論研究一年

2002年6月,畢業(yè)于武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院獲理學(xué)博士學(xué)位

工作經(jīng)歷

2001年7月,入職于武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院從事高分子教學(xué)和科研

2008年10月,獲日本學(xué)術(shù)振興學(xué)會（JSPS）資助赴神戶大學(xué)從事多糖的結(jié)構(gòu)-活性相關(guān)性研究二年

研究方向

天然高分子

1、多糖的多尺度結(jié)構(gòu)、溶液性質(zhì)及品質(zhì)功能

2、多糖基微納米材料

3、多糖的生物活性、構(gòu)效關(guān)系及作用機(jī)制

代表成果

1. Liqin Cai?, Shujun Zhou?, Xiaojuan Xu*, Yanfeng Wang*, Zongwei Cai*, Lina Zhang. The composites of triple-helix glucan nanotubes/selenium nanoparticles target hepatocellular carcinoma to enhance ferroptosis by depleting glutathione and augmenting redox imbalance. Chem. Eng. J. 2022, 446(3): 137110.

2. Liqin Cai, Lina Zhang, Xiaojuan Xu*. One-step synthesis of ultra-small silver nanoparticles-loaded triple-helix β-glucan nanocomposite for highly catalytic hydrogenation of 4-nitrophenol and dyes. Chem. Eng. J. 2022, 442(1): 136114.

3. Huanhuan Chen^#, Ying Sun^#, Xiaojuan Xu*, Qifa Ye*. Targeted delivery of methotrexate by modified yeast β-glucan nanoparticles for rheumatoid arthritis therapy. Carbohydr. Polym. 2022, 284: 119183.

4. Bingchao Duan, Ying Sun, Siwei Zou, Xiaojuan Xu*. Fabrication of tumor-targeting composites based on the triple helical a-glucan through conjugation of aptamer. Carbohydr. Polym. 2021, 254: 117476.

5. Ying Sun, Bingchao Duan, Huanhuan Chen, Xiaojuan Xu*. A novel strategy for treating inflammatory bowel disease by targeting delivery of methotrexate through glucan particles. Adv. Healthcare Mater. 2020, 9 (6): 1901805.

6. Siwei Zou, Bingchao Duan, Xiaojuan Xu*. Inhibition of tumor growth by b-glucans through promoting CD4⁺ T cell immunomodulation and neutrophil-killing in mice. Carbohydr. Polym. 2019, 213: 370-381. 25.

7. Bingchao Duan^#, Mengxia Li^#, Ying Sun, Siwei Zou, Xiaojuan Xu*. Orally delivered antisense oligodeoxyribonucleotides of TNF-a via polysaccharide-based nanocomposites targeting intestinal inflammation. Adv. Healthcare Mater. 2019, 8(5): 1801389.

8. Bingchao Duan, Ying Sun, Siwei Zou, Xiaojuan Xu*. Nanoplatform constructed from a β-glucan and polydeoxyadenylic acid for cancer chemotherapy and imaging. Biomacromolecules 2019, 20 (4): 1567–1577.

9. Yan Meng, Xiaodan Shi, Liqin Cai, Sihai Zhang, Kan Ding, Shaoping Nie, Chuanfu Luo*, Xiaojuan Xu*, Lina Zhang*. Triple helix conformation of a polysaccharide determined with light scattering, AFM and molecular dynamic simulation. Macromolecules 2018, 51 (24): 10150

10. Zhaohua Ping, Ting Liu, Hui Xu, Yan Meng, Wenhua Li, Xiaojuan Xu*, Lina Zhang*. Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities. Nano Res. 2017, 10: 3775–3789.