個(gè)人簡介

武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院副教授，博士生導(dǎo)師

圍繞著修飾核酸，包括表觀遺傳學(xué)修飾以及人工修飾的核酸，在核酸的測序、檢測、調(diào)控方面取得了一些成果，開發(fā)出針對(duì)特定修飾堿基的測序方法，發(fā)現(xiàn)了一些比較好的檢測方法和調(diào)控手段，下一步我們希望在現(xiàn)有基礎(chǔ)上利用這些研究方法和手段，能夠在基因?qū)用嫔蠈?duì)相關(guān)的生物功能和機(jī)理的研究取得一些突破，并真正將檢測技術(shù)應(yīng)用于臨床疾病的早期檢測和診斷。承擔(dān)項(xiàng)目與課題1. 國家自然科學(xué)基金面上項(xiàng)目(2023)，基于鄰近誘導(dǎo)化學(xué)的表觀遺傳修飾核酸結(jié)合蛋白的標(biāo)記方法；2. 國家自然科學(xué)基金重點(diǎn)項(xiàng)目(2021) G-四鏈核酸的分子識(shí)別機(jī)制與功能的研究。3. 國家自然科學(xué)基金面上項(xiàng)目(2016)， DNA中甲基、羥甲基、醛基胞嘧啶多位點(diǎn)檢測及胞嘧啶羥甲基修飾的方法研究；4. 國家自然科學(xué)基金青年基金(2014)，新型可誘導(dǎo)DNA甲基轉(zhuǎn)移酶和組蛋白甲基轉(zhuǎn)移酶抑制劑的設(shè)計(jì)合成,構(gòu)效關(guān)系和活性研究。

教育經(jīng)歷

2000.09-2004.06 武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院 大學(xué)本科

2004.09-2010.07 武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院 博士研究生

2007.09-2008.09 格勒諾布爾一大化學(xué)系 聯(lián)合培養(yǎng)研究生

工作經(jīng)歷

2009.01-2010.01 弗吉尼亞大學(xué)化學(xué)系 訪問學(xué)者

2013.04-至今 武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院 副教授

研究方向

開發(fā)修飾堿基測序方法、小分子探針的開發(fā)、核酸表觀遺傳修飾的檢測

代表成果

[1] Zhaoxin Chen, Hanfei Zhang, Feng Xiao, Shen Yan, Linao Ren, Song-Mei Liu, Xiaocheng Weng, Xiang Zhou*, Yuhao Du*, Anal Chem. 2024, 96, 13103-13109

[2] Shen Yan, Ziang Lu, Wei Yang, Jinglei Xu, Yafen Wang, Wei Xiong, Rongjie Zhu, Linao Ren, Zhaoxin Chen, Qi Wei, Song-mei Liu, Tian Feng, Bifeng Yuan, Xiaocheng Weng, Yuhao Du*, Xiang Zhou*, Antibody-Free Fluorine-Assisted Metabolic Sequencing of RNA N⁴-Acetylcytidine. J Am Chem Soc. 2023, 145, 22232-22242..

[3] Zhang Y.; Yan S.; Chen Z.; Jiang X.; Rao S.; Jiang Z.; Qin S.; Zhou X. *; Du Y. *; Visually Intracellular Detection of Telomerase Activity Based on DNA Strand Displacement Reaction and Gold Nanoparticle Labeling, Chin. J. Chem, 2022, 40: 693-698

[4] Yajun Zhang; Qiuyang Zhang; Xiaocheng Weng; Yuhao Du*; Xiang Zhou*; NEase-based amplificat ion for detection of miRNA, multiple miRNAs and circRNA, Analytica Chimica Acta, 2021, 1145: 52-5 8

[5] Yaqian Liu, Xiong Zhang, Min Liu, Fa Xu, Qiuyang Zhang, Yajun Zhang, Xiaocheng Weng, Songmei Liu, Yuhao Du*, Xiang Zhou, Direct detection of circRNA in real samples using reverse transcription-rolling circle ampli?cation, Anal. Chim. Acta., 2020, 1101: 169-175,

[6] Min Liu, Wu Fan, Yuhao Du*, Xiang Zhou*, Specific stabilization of DNA G-quadruplex structures with a chemically modified complementary probe，Bioorg. Med. Chem. 2019, 27, 1962

[7] Yinong Liu, Cheng Zhong, Zhiyong He, Shuang Rao, Haomiao Su, Fan Wu, Boshi Fu, Jinjun Wu, Yanyan Song, Yuhao Du*, and Xiang Zhou* . Sensors and Actuators B, 2018, 255, 2151

[8] Zhiyong He, Chen, Yuqi Chen, Yafen Wang, Jiaqi Wang, Jing Mo, Boshi Fu, Zijing Wang, Xiang Zhou*, Yuhao Du*, A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing, Chem. Commun, 2016, 52, 8545.

[9] Shuang Rao, Yuqi Chen, Tingting Hong, Zhiyong He, Shan Guo, Han Lai, Ge Guo, Yuhao Du*，Xiang Zhou*，Simultaneous and Sensitive Detection of Multisite 5-Methylcytosine Including Non-CpG Sites at Single-5mC-Resolution. Anal. Chem, 2016, 88, 10547.

[10] Yuhao Du*, Xiang Zhou*, Targeting non-B-form DNA in living cells. Chem. Rec, 2013, 371.

[11] Yuhao Du, Charles Hendrick, Krysta Frye, Lindsay Comstock*, Fluorescent DNA labeling by N-mustard analogues of S-adenosyl-L-methionine. ChemBioChem, 2012, 13, 2225.

[12] Mark Turlington, Yuhao Du, Samuel G Ostrum, Wren Vishaka, Tony Lin, Michal Sabat，Lin Pu*, From highly enantioselective catalytic reaction of 1,3-diynes with aldehydes to facile asymmetric synthesis of polycyclic compounds. J. Am. Chem. Soc., 2011, 133, 11780。

[13] Yuhao Du, , Xiaocheng Weng, Jing Huang, Dan Zhang, Heng Ma, Dong Chen, Xiang Zhou*, Constant, Jean-Francois, Oligonucleotide-selenide conjugate: synthesis and its inducible sequence-specific alkylation of DNA. Bioorg. Med. Chem. 2010, 18, 4149.

[14] Yuhao Du, Mark Turlington, Xiang Zhou, Lin Pu*, Highly enantioselective addition of linear alkyl alkynes to linear aldehydes. Tetrahedron Lett., 2010, 51, 5024. (IF: 2.259, 三區(qū))

[15] Yuhao Du, Dan Zhang, Wei Chen, Ming Zhang, Yangyang Zhou, Xiang Zhou*, Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition. Bioorg. Med. Chem. 2010, 18, 1111.

[16] Yuhao Du, Jing Huang, Xiaocheng Weng, Xiang Zhou*, Specific Recognition of DNA by Small Molecules. Curr. Med. Chem. 2010, 17, 173.