個人簡介
田沺，教授、博士生導師、國家優(yōu)青獲得者、武漢大學珞珈青年學者
教育經(jīng)歷
2000.09-2004.06 武漢大學化學與分子科學學院 大學本科 導師：萬婕教授
2004.09-2009.06 武漢大學化學與分子科學學院 博士研究生 導師：周翔教授
2010.05-2012.05 武漢大學生命科學學院 博士后 合作導師：吳建國教授
工作經(jīng)歷
2012.11-2015.10 武漢大學化學與分子科學學院 副教授
2015.11-至今 武漢大學化學與分子科學學院 教授
研究方向
主要科研工作圍繞核酸化學生物學開展工作，主要針對特殊二級結(jié)構(gòu)核酸(G-四鏈核酸、左手螺旋核酸Z-DNA)以及修飾核酸，進行結(jié)構(gòu)與功能研究；發(fā)展小分子探針策略，對核酸的結(jié)構(gòu)和功能進行調(diào)控；進一步拓展以特殊二級結(jié)構(gòu)核酸為靶標的創(chuàng)新藥物設(shè)計和調(diào)控工具系統(tǒng)；重點解決傳統(tǒng)方向以外的新功能揭示以及創(chuàng)新應(yīng)用拓展。
代表成果
1. Shaoru Wang#, Lingyu Wu#, Haiyan Huang#, Wei Xiong, Jian Liu, Lai Wei, Ping Yin, Tian Tian*, Xiang Zhou*. Conditional control of RNA-guided nucleic acid cleavage and gene editing. Nature Communications, 2020, 11, 91.
2. Shaoru Wang#, Haiyan Huang#, Jian Liu, Lai Wei, Lingyu Wu, Wei Xiong, Ping Yin, Tian Tian*, Xiang Zhou*. The manipulation of RNA-guided nucleic acid cleavage with ninhydrin chemistry. Advanced Science, 2020, 11, 1903770.
3.Wang, S. R.#; Min, Y. Q.#; Wang, J. Q.; Liu, C. X.; Fu, B. S.; Wu, F.; Wu, L. Y.; Qiao, Z. X.; Song, Y. Y.; Xu, G. H.; Wu, Z. G.; Huang, G.; Peng, N. F.; Huang, R.; Mao, W. X.; Peng, S.; Chen, Y. Q.; Zhu, Y.;Tian, T.*; Zhang, X. L. *; Zhou, X. *, A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target.Science Advances2016,2(4), e1501535. (Science子刊)
4.Tian, T.#; Chen, Y.#; Wang, S.*; Zhou, X.*, G-Quadruplex: A Regulator of Gene Expression and Its Chemical Targeting.Chem 2018,4, 1314-1344. (Cell子刊)
5. Wang, S. R.#; Zhang, Q. Y.#; Wang, J. Q.#; Ge, X. Y.; Song, Y. Y.; Wang, Y. F.; Li, X. D.; Fu, B. S.; Xu, G. H.; Shu, B.; Gong, P.; Zhang, B. *;Tian, T.*; Zhou, X. *, Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene.Cell Chemical Biology2016,23(9), 1113-22. (Cell子刊)
6. Wang, S.#; Song, Y.#; Wei, L.; Liu, C.; Fu, B.; Wang, J.; Yang, X.; Liu, Y.; Liu, S.;Tian, T.*; Zhou, X.*, Cucurbit[7]uril-Driven Host-Guest Chemistry for Reversible Intervention of 5-Formylcytosine-Targeted Biochemical Reactions.Journal of the American Chemical Society2017,139(46), 16903-12.
7.Tian, T.#; Song, Y.#; Wang, J.; Fu, B.; He, Z.; Xu, X.; Li, A.; Zhou, X.; Wang, S. *; Zhou, X. *, Small-Molecule-Triggered and Light-Controlled Reversible Regulation of Enzymatic Activity.Journal of the American Chemical Society2016,138(3), 955-61.
8. Wang, S.; Long, Y.; Wang, J.; Ge, Y.; Guo, P.; Liu, Y.;Tian, T.*; Zhou, X. *, Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: the effects on the B-Z transition.Journal of the American Chemical Society2014,136(1), 56-9.
9.Tian, T.#; Song, Y.#; Wei, L.#; Wang, J.; Fu, B.; He, Z.; Yang, X. R.; Wu, F.; Xu, G.; Liu, S. M.; Li, C.; Wang, S. *; Zhou, X. *, Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions.Nucleic Acids Research2017,45(5), 2283-2293.
10. Wang, S.#; Song, Y.#; Wang, Y.; Li, X.; Fu, B.; Liu, Y.; Wang, J.; Wei, L.;Tian, T.*; Zhou, X. *, The m6A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide.Chemical Science2017,8(9), 6380-6388.
